Prof. Tamas Lazar

10% Asst. Prof. at VUB DBIT-SBB and 90% Senior PostDoc at Bio2Byte lab of VUB

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Hello, I’m Tamas Lazar 👋

Welcome to my personal GitHub website. I am a bioinformatician working at the interface of protein biophysics, structural biology and machine learning.

Mini‑Bio

• Assistant Professor (10%) at Vrije Universiteit Brussel (VUB)
• Senior Postdoctoral Researcher in the Bio2Byte group at the Interuniversity Institute for Bioinformatics Brussels (IB)²
• Member of the Young Academy of Flanders - Belgium (Jonge Academie)
• Previously held research roles at VIB-VUB Center Struct. Biol. (CSB)
• PhD obtained in Bio-engineering from VUB, Belgium
• MSc in Medical Biotech. from Semmelweis Medical Uni., Hungary
• BSc in Molecular Bionics Eng. from PPCU, Budapest, Hungary

Projects

• BE-PROTECT — research on biological threats, biosafety and risk assessment based on protein analysis.
• Protein variant analysis in pathobiology
• Structure - disorder - dynamics - function - evolution relationships in proteins
• Protein design for biotechnological applications
• Computational biology method development and pipeline design

Supervision (current and past)

• Wout De Muer (2026-2030): PhD co-supervision (VLAIO mandate)
• Tiara Amirasyam (2026): Master internship supervision for 2 months
• Srijaani Sankar Datta (2026): Master internship supervision for 4 months
• Amin Alizadeh (2026): Pre-PhD internship supervision for 3 months
• Hiba Chehab (2025): Master internship supervision for 1 month
• Evagelos Efremidis (2023): Pre-PhD internship supervision for 5 months
• MSCA IDPfun secondees (2019-2023): 10+ co-supervision of secondments for 3-6 months
• Nazanin Farahi (2020-2021): Master thesis co-supervision for 1 year

Selected recent publications

• Pedrelli, G. et al. “Negative design enables cell-free expression and folding of designed transmembrane β-Barrels.” Proc. Natl. Acad. Sci. U.S.A. (2026).
• Durán-Armenta, L. F. et al. “Expression and Purification of Full-Length hnRNPA2B1 for Biophysical Characterization of Liquid-Liquid Phase Separation.” Protein Expr. Purif. (2026).
• Kalman, Z. E. et al. “Definition and discovery of tandem SH3-binding motifs interacting with members of the p47phox-related protein family.” Biomolecules (2025).
• Lazar, T. et al. “Targeting protein disorder: the next hurdle in drug discovery.” Nature Reviews Drug Discovery (2025).
• Farahi, N. & Lazar, T. et al. “Phase-separating fusion proteins drive cancer by upsetting transcription regulation.” Genome Biology (2025).
• Navarro, A. M. et al. “Unveiling the Complexity of cis‑Regulation Mechanisms in Kinases: A Comprehensive Analysis.” Proteins: Structure, Function, and Bioinformatics (2025).
• Ramos, L. L. P. et al. “Monoallelic POLR3A variants cause a Pol III-related disorder characterized by peripheral neuropathy.” medRxiv (2025).
• Van Nerom, M. et al. “C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1.” Proc. Natl. Acad. Sci. U.S.A. (2024).
• Jiao, X. et al. “A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription.” Oncogenesis (2024).
• Aspromonte, M. C. et al. “DisProt in 2024: improving function annotation of intrinsically disordered proteins.” Nucleic Acids Research (2024).
• Kumar, M. et al. “ELM—the Eukaryotic Linear Motif resource—2024 update.” Nucleic Acids Research (2024).
• Ghafouri, H. & Lazar, T. et al. “PED in 2024: improving the community deposition of structural ensembles for intrinsically disordered proteins.” Nucleic Acids Research (2023).
• Efraimidis, E. et al. “In Silico Structural Analysis Exploring Conformational Folding of Protein Variants in Alzheimer’s Disease.” International Journal of Molecular Sciences (2023).
• Amor-Barris, S. & Lazar, T. et al. “Structural clustering and functional profiling of NMAN-causing variants in HINT1 suggest personalized therapeutic strategies.” biorXiv (2023).

Contact

You can email me on this address: tamas.lazar@vub.be

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